Structural Insights and Development of LRRK2 Inhibitors for Parkinson’s Disease in the Last Decade

Structural Insights and Development of LRRK2 Inhibitors for Parkinson’s Disease in the Last Decade

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease, characterized by the specific loss of dopaminergic neurons in the midbrain. The pathophysiology of PD is likely caused by a variety of environmental and hereditary factors. Many single-gene mutations have been linked to...

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Bibliographic Details
Main Authors: Gunjan Thakur, Vikas Kumar, Keun Woo Lee, Chungkil Won
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Genes
Subjects:
G2019S mutation
kinase inhibitors
LRRK2
neurodegeneration
Parkinson’s disease
Online Access:https://www.mdpi.com/2073-4425/13/8/1426

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https://www.mdpi.com/2073-4425/13/8/1426

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