Validation of the XTT-test for assessing the antiproliferative activity of biologics on the basis of monoclonal antibodies

Using the example of Herceptin (Roche) a method of assessing the antiproliferative activity of monoclonal antibodies using tetrazolium salt was developed. The method is based on spectrometric measurement of the level of formazan transformed by living cells from a water soluble salt XTT. The level of...

Full description

Bibliographic Details
Main Authors: I. V. Lyagoskin, M. A. Berestovoy, D. A. Poteryaev, E. S. Zeinalova, A. Yu. Vishnevskiy, A. A. Kazarov
Format: Article
Language:Russian
Published: Ministry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» 2018-02-01
Series:Биопрепараты: Профилактика, диагностика, лечение
Subjects:
Online Access:https://www.biopreparations.ru/jour/article/view/6