Modeling to capture bystander-killing effect by released payload in target positive tumor cells

Modeling to capture bystander-killing effect by released payload in target positive tumor cells

Abstract Background Antibody-drug conjugates (ADCs) are intended to bind to specific positive target antigens and eradicate only tumor cells from an intracellular released payload through the lysosomal protease. Payloads, such as MMAE, have the capacity to kill adjacent antigen-negative (Ag–) tumor...

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Bibliographic Details
Main Authors: Jong Hyuk Byun, Il Hyo Jung
Format: Article
Language:English
Published: BMC 2019-03-01
Series:BMC Cancer
Subjects:
Bystander-killing effect in ADCs
Antibody-drug conjugates (ADCs)
Dose-response curve
Age-structure model
Tumor growth inhibition (TGI) model
Online Access:http://link.springer.com/article/10.1186/s12885-019-5336-7

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http://link.springer.com/article/10.1186/s12885-019-5336-7

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