Janus kinase (JAK) inhibitors in the treatment of neoplastic and inflammatory disorders

Janus kinase (JAK) inhibitors in the treatment of neoplastic and inflammatory disorders

The Janus kinase (JAK) family of nonreceptor protein-tyrosine kinases consists of JAK1, JAK2, JAK3, and TYK2 (Tyrosine Kinase 2). Each of these proteins contains a JAK homology pseudokinase (JH2) domain that interacts with and regulates the activity of the adjacent protein kinase domain (JH1). The J...

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Bibliographic Details
Main Author: Robert Roskoski, Jr.
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Pharmacological Research
Subjects:
Atopic dermatitis
Leukemia
Myelofibrosis
Polycythemia vera
Rheumatoid arthritis
STAT
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661822003073

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http://www.sciencedirect.com/science/article/pii/S1043661822003073

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