Evidence for widespread dysregulation of circadian clock progression in human cancer

The ubiquitous daily rhythms in mammalian physiology are guided by progression of the circadian clock. In mice, systemic disruption of the clock can promote tumor growth. In vitro, multiple oncogenes can disrupt the clock. However, due to the difficulties of studying circadian rhythms in solid tissu...

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Bibliographic Details
Main Authors: Jarrod Shilts, Guanhua Chen, Jacob J. Hughey
Format: Article
Language:English
Published: PeerJ Inc. 2018-01-01
Series:PeerJ
Subjects:
Online Access:https://peerj.com/articles/4327.pdf