Creating PWMs of transcription factors using 3D structure-based computation of protein-DNA free binding energies

<p>Abstract</p> <p>Background</p> <p>Knowledge of transcription factor-DNA binding patterns is crucial for understanding gene transcription. Numerous DNA-binding proteins are annotated as transcription factors in the literature, however, for many of them the correspondi...

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Bibliographic Details
Main Authors: Stegmaier Philip, Alamanova Denitsa, Kel Alexander
Format: Article
Language:English
Published: BMC 2010-05-01
Series:BMC Bioinformatics
Online Access:http://www.biomedcentral.com/1471-2105/11/225