The endogenous Th17 response in NO2-promoted allergic airway disease is dispensable for airway hyperresponsiveness and distinct from Th17 adoptive transfer.

The endogenous Th17 response in NO2-promoted allergic airway disease is dispensable for airway hyperresponsiveness and distinct from Th17 adoptive transfer.

Severe, glucocorticoid-resistant asthma comprises 5-7% of patients with asthma. IL-17 is a biomarker of severe asthma, and the adoptive transfer of Th17 cells in mice is sufficient to induce glucocorticoid-resistant allergic airway disease. Nitrogen dioxide (NO2) is an environmental toxin that corre...

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Bibliographic Details
Main Authors: Rebecca A Martin, Jennifer L Ather, Rebecca Daggett, Laura Hoyt, John F Alcorn, Benjamin T Suratt, Daniel J Weiss, Lennart K A Lundblad, Matthew E Poynter
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3778003?pdf=render

Internet

http://europepmc.org/articles/PMC3778003?pdf=render

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