Effects of Apamin on MPP<sup>+</sup>-Induced Calcium Overload and Neurotoxicity by Targeting CaMKII/ERK/p65/STAT3 Signaling Pathways in Dopaminergic Neuronal Cells

Effects of Apamin on MPP<sup>+</sup>-Induced Calcium Overload and Neurotoxicity by Targeting CaMKII/ERK/p65/STAT3 Signaling Pathways in Dopaminergic Neuronal Cells

Parkinson’s disease (PD), a neurodegenerative disorder, is characterized by the loss of dopaminergic (DA) neurons. The pathogenesis of PD is associated with several factors including oxidative stress, inflammation, and mitochondrial dysfunction. Ca<sup>2+</sup> signaling plays a vital ro...

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Bibliographic Details
Main Authors: Jihyun Park, Kyung Mi Jang, Kwan-Kyu Park
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
Parkinson’s disease
apamin
SK channel
oxidant stress
ROS
apoptosis
Online Access:https://www.mdpi.com/1422-0067/23/23/15255

Internet

https://www.mdpi.com/1422-0067/23/23/15255

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