Loss of TET2 impairs endothelial angiogenesis via downregulating STAT3 target genes

Loss of TET2 impairs endothelial angiogenesis via downregulating STAT3 target genes

Abstract Background Ischemic diseases represent a major global health care burden. Angiogenesis is critical in recovery of blood flow and repair of injured tissue in ischemic diseases. Ten–eleven translocation protein 2 (TET2), a member of DNA demethylases, is involved in many pathological processes...

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Bibliographic Details
Main Authors: Yefei Shi, Bo Li, Xinru Huang, Wenxin Kou, Ming Zhai, Yanxi Zeng, Shuangjie You, Qing Yu, Yifan Zhao, Jianhui Zhuang, Wenhui Peng, Weixia Jian
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Cell & Bioscience
Subjects:
TET2
5-hmC
STAT3
Angiogenesis
Ischemic diseases
Online Access:https://doi.org/10.1186/s13578-023-00960-5

Internet

https://doi.org/10.1186/s13578-023-00960-5

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