The Shiga Toxin Receptor Globotriaosylceramide as Therapeutic Target in Shiga Toxin <i>E. coli</i> Mediated HUS

The Shiga Toxin Receptor Globotriaosylceramide as Therapeutic Target in Shiga Toxin <i>E. coli</i> Mediated HUS

In 90% of the cases, childhood hemolytic uremic syndrome (HUS) is caused by an infection with the Shiga toxin (Stx) producing <i>E. coli</i> bacteria (STEC-HUS). Stx preferentially binds to its receptor, the glycosphingolipid, globotriaosylceramide (Gb3), present on the surface of human...

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Bibliographic Details
Main Authors: Wouter J. C. Feitz, Romy Bouwmeester, Thea J. A. M. van der Velden, Susan Goorden, Christoph Licht, Lambert P. J. W. van den Heuvel, Nicole C. A. J. van de Kar
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Microorganisms
Subjects:
STEC-HUS
shiga toxin
endothelial cells
globotriaosylceramide
glucosylceramide synthase
eliglustat
Online Access:https://www.mdpi.com/2076-2607/9/10/2157

Internet

https://www.mdpi.com/2076-2607/9/10/2157

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