Finding an Appropriate Mouse Model to Study the Impact of a Treatment for Friedreich Ataxia on the Behavioral Phenotype

Finding an Appropriate Mouse Model to Study the Impact of a Treatment for Friedreich Ataxia on the Behavioral Phenotype

Friedreich ataxia (FRDA) is a progressive neurodegenerative disease caused by a GAA repeat in the intron 1 of the frataxin gene (FXN) leading to a lower expression of the frataxin protein. The YG8sR mice are Knock-Out (KO) for their murine frataxin gene but contain a human frataxin transgene derived...

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Bibliographic Details
Main Authors: Camille Bouchard, Catherine Gérard, Solange Gni-fiene Yanyabé, Nathalie Majeau, Malek Aloui, Gabrielle Buisson, Pouiré Yameogo, Vanessa Couture, Jacques P. Tremblay
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Genes
Subjects:
Friedreich ataxia
mouse model
phenotype
frataxin
shRNA
Online Access:https://www.mdpi.com/2073-4425/14/8/1654

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https://www.mdpi.com/2073-4425/14/8/1654

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