BOMA, a machine-learning framework for comparative gene expression analysis across brains and organoids

BOMA, a machine-learning framework for comparative gene expression analysis across brains and organoids

Summary: Our machine-learning framework, brain and organoid manifold alignment (BOMA), first performs a global alignment of developmental gene expression data between brains and organoids. It then applies manifold learning to locally refine the alignment, revealing conserved and specific development...

Full description

Bibliographic Details
Main Authors: Chenfeng He, Noah Cohen Kalafut, Soraya O. Sandoval, Ryan Risgaard, Carissa L. Sirois, Chen Yang, Saniya Khullar, Marin Suzuki, Xiang Huang, Qiang Chang, Xinyu Zhao, Andre M.M. Sousa, Daifeng Wang
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Cell Reports: Methods
Subjects:
CP: Stem cell
CP: Systems biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2667237523000206

Internet

http://www.sciencedirect.com/science/article/pii/S2667237523000206

Similar Items