Palmitic Acid, but Not Lauric Acid, Induces Metabolic Inflammation, Mitochondrial Fragmentation, and a Drop in Mitochondrial Membrane Potential in Human Primary Myotubes

The chain length of saturated fatty acids may dictate their impact on inflammation and mitochondrial dysfunction, two pivotal players in the pathogenesis of insulin resistance. However, these paradigms have only been investigated in animal models and cell lines so far. Thus, the aim of this study wa...

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Bibliographic Details
Main Authors: Domenico Sergi, Natalie Luscombe-Marsh, Nenad Naumovski, Mahinda Abeywardena, Nathan O'Callaghan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Nutrition
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2021.663838/full