Fructose Induces Pulmonary Fibrotic Phenotype Through Promoting Epithelial-Mesenchymal Transition Mediated by ROS-Activated Latent TGF-β1

Fructose Induces Pulmonary Fibrotic Phenotype Through Promoting Epithelial-Mesenchymal Transition Mediated by ROS-Activated Latent TGF-β1

Fructose is a commonly used food additive and has many adverse effects on human health, but it is unclear whether fructose impacts pulmonary fibrosis. TGF-β1, a potent fibrotic inducer, is produced as latent complexes by various cells, including alveolar epithelial cells, macrophages, and fibroblast...

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Bibliographic Details
Main Authors: Xiaoxiao Xu, Chuang Ma, Hang Wu, Yuanqiao Ma, Zejin Liu, Peijie Zhong, Chaolei Jin, Wenjuan Ning, Xiao Wu, Yijie Zhang, Jichang Han, Junpeng Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Nutrition
Subjects:
fructose
pulmonary fibrosis
epithelial-mesenchymal transition
latent TGF-β
ROS
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2022.850689/full

Internet

https://www.frontiersin.org/articles/10.3389/fnut.2022.850689/full

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