Presence of Systemic Amyloidosis in Mice with Partial Deficiency in Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Aging

Presence of Systemic Amyloidosis in Mice with Partial Deficiency in Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Aging

Pituitary adenylate cyclase-activating polypeptide (PACAP), a neuropeptide with widespread expression and general cytoprotective effects, is also involved in aging. Previously, we observed accelerated systemic senile amyloidosis in PACAP knockout (KO) mice. As mice partially lacking PACAP (heterozyg...

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Bibliographic Details
Main Authors: Jason Sparks, Adel Jungling, Gabriella Kiss, Laszlo Hiripi, Daniel Pham, Andrea Tamas, Orsolya Hoffmann, Sebastian Bardosi, Attila Miseta, Dora Reglodi
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Applied Sciences
Subjects:
PACAP
deficiency
amyloidosis
PAC1 receptor
blood formation
aging
Online Access:https://www.mdpi.com/2076-3417/11/16/7373

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https://www.mdpi.com/2076-3417/11/16/7373

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