Fibrodysplasia ossificans progressiva mutant ACVR1 signals by multiple modalities in the developing zebrafish

Fibrodysplasia ossificans progressiva mutant ACVR1 signals by multiple modalities in the developing zebrafish

Fibrodysplasia ossificans progressiva (FOP) is a rare human genetic disorder characterized by altered skeletal development and extraskeletal ossification. All cases of FOP are caused by activating mutations in the type I BMP/TGFβ cell surface receptor ACVR1, which over-activates signaling through ph...

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Bibliographic Details
Main Authors: Robyn S Allen, Benjamin Tajer, Eileen M Shore, Mary C Mullins
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-09-01
Series:eLife
Subjects:
bmp signaling
fibrodysplasia ossificans progressiva
ligand-binding independent signaling
ligand-responsive signaling
dorsal-ventral patterning
Online Access:https://elifesciences.org/articles/53761

Internet

https://elifesciences.org/articles/53761

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