SIRT5 Desuccinylates and Activates Pyruvate Kinase M2 to Block Macrophage IL-1β Production and to Prevent DSS-Induced Colitis in Mice

SIRT5 Desuccinylates and Activates Pyruvate Kinase M2 to Block Macrophage IL-1β Production and to Prevent DSS-Induced Colitis in Mice

LPS-activated macrophages undergo a metabolic shift from dependence on mitochondria-produced ATP to reliance on aerobic glycolysis, where PKM2 is a critical determinant. Here, we show that PKM2 is a physiological substrate of SIRT5 and that SIRT5-regulated hypersuccinylation inhibits the pyruvate ki...

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Bibliographic Details
Main Authors: Fang Wang, Ke Wang, Wei Xu, Shimin Zhao, Dan Ye, Yi Wang, Ying Xu, Lisha Zhou, Yiwei Chu, Cuiping Zhang, Xue Qin, Pengyuan Yang, Hongxiu Yu
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Cell Reports
Subjects:
SIRT5
PKM2
succinylation
IL-1β
macrophages
colitis
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717307222

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http://www.sciencedirect.com/science/article/pii/S2211124717307222

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