MEndoB, a chimeric lysin featuring a novel domain architecture and superior activity for the treatment of staphylococcal infections

MEndoB, a chimeric lysin featuring a novel domain architecture and superior activity for the treatment of staphylococcal infections

ABSTRACT Bacterial infections are a growing global healthcare concern, as an estimated annual 4.95 million deaths are associated with antimicrobial resistance (AMR). Methicillin-resistant Staphylococcus aureus is one of the deadliest pathogens and a high-priority pathogen according to the World Heal...

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Bibliographic Details
Main Authors: Christian Roehrig, Markus Huemer, Dominique Lorgé, Fabienne Arn, Nadine Heinrich, Lavanja Selvakumar, Lynn Gasser, Patrick Hauswirth, Chun-Chi Chang, Tiziano A. Schweizer, Fritz Eichenseher, Steffi Lehmann, Annelies S. Zinkernagel, Mathias Schmelcher
Format: Article
Language:English
Published: American Society for Microbiology 2024-02-01
Series:mBio
Subjects:
antibiotic resistance
endolysin
bacteriophage
MRSA
bacteremia
peptidoglycan hydrolase
Online Access:https://journals.asm.org/doi/10.1128/mbio.02540-23

Internet

https://journals.asm.org/doi/10.1128/mbio.02540-23

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