Rosuvastatin suppresses TNF-α-induced matrix catabolism, pyroptosis and senescence via the HMGB1/NF-κB signaling pathway in nucleus pulposus cells

Rosuvastatin suppresses TNF-α-induced matrix catabolism, pyroptosis and senescence via the HMGB1/NF-κB signaling pathway in nucleus pulposus cells

Intervertebral disc degeneration is mainly caused by irregular matrix metabolism in nucleus pulposus cells and involves inflammatory factors such as TNF-α. Rosuvastatin, which is widely used in the clinic to reduce cholesterol levels, exerts anti-inflammatory effects, but whether rosuvastatin partic...

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Bibliographic Details
Main Authors: Chen Weijian, Deng Zhihuai, Zhu Jianxiong, Yuan Liang, Li Shuangxing, Zhang Yangyang, Wu Jiajun, Huang Zhengqi, Qin Tianyu, Ye Wei
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2023-05-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
intervertebral disc degeneration
rosuvastatin
high-mobility group box 1
NF-κB signaling pathway
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2023026

Internet

https://www.sciengine.com/doi/10.3724/abbs.2023026

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