Cellular cholesterol loss by DHCR24 knockdown leads to Aβ production by changing APP intracellular localization

Cellular cholesterol loss by DHCR24 knockdown leads to Aβ production by changing APP intracellular localization

For the past 20 years, the majority of cell culture studies reported that increasing cholesterol level increases amyloid-β (Aβ) production. Conversely, other studies and genetic evidences support that cellular cholesterol loss leads to Aβ generation. As a highly controversial issue in Alzheimer’s di...

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Bibliographic Details
Main Authors: Yue Huang, Wenbin Zhang, Xiaorou Guo, Ying Zhang, Junfeng Wu, Hengbing Zu
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Journal of Lipid Research
Subjects:
Alzheimer’s disease
APP
Amyloid-β
DHCR24
Cholesterol
Pathogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227523000408

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http://www.sciencedirect.com/science/article/pii/S0022227523000408

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