Exploring Biginelli-based scaffolds as A2B adenosine receptor antagonists: Unveiling novel structure-activity relationship trends, lead compounds, and potent colorectal anticancer agents

Exploring Biginelli-based scaffolds as A2B adenosine receptor antagonists: Unveiling novel structure-activity relationship trends, lead compounds, and potent colorectal anticancer agents

Antagonists of the A2B adenosine receptor have recently emerged as targeted anticancer agents and immune checkpoint inhibitors within the realm of cancer immunotherapy. This study presents a comprehensive evaluation of novel Biginelli-assembled pyrimidine chemotypes, including mono-, bi-, and tricyc...

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Bibliographic Details
Main Authors: Rubén Prieto-Díaz, Hugo Fojo-Carballo, Maria Majellaro, Tana Tandarić, Jhonny Azuaje, José Brea, María I. Loza, Jorge Barbazán, Glòria Salort, Meera Chotalia, Iván Rodríguez-Pampín, Ana Mallo-Abreu, M. Rita Paleo, Xerardo García-Mera, Francisco Ciruela, Hugo Gutiérrez-de-Terán, Eddy Sotelo
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Biomedicine & Pharmacotherapy
Subjects:
A2B adenosine receptor
Colorectal cancer
Biginelli reaction
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332224002294

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http://www.sciencedirect.com/science/article/pii/S0753332224002294

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