Thioridazine combined with carboplatin results in synergistic inhibition of triple negative breast cancer by targeting cancer stem cells

Thioridazine combined with carboplatin results in synergistic inhibition of triple negative breast cancer by targeting cancer stem cells

Cancer stem cells (CSCs) in triple-negative breast cancer (TNBC) are closely related to tumorigenesis and metastasis. Thioridazine (THZ) is a usual phenothiazine antipsychotic drug that can destroy CSCs. We aimed to explore whether THZ could sensitize metastatic TNBC cells, especially the CSCs, to c...

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Bibliographic Details
Main Authors: Yi Wang, Leiming Xia, Jing Lin, Li Gong, Yang Xia, Yang Xu, Liu Liu, Jian Bao, Congshu Zhang, Yuqing Chai, Hongxia Li
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Translational Oncology
Subjects:
Cancer stem cells
Carboplatin
Synergistic inhibition
Lung metastasis
Thioridazine
Online Access:http://www.sciencedirect.com/science/article/pii/S193652332200208X

Internet

http://www.sciencedirect.com/science/article/pii/S193652332200208X

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