Renal and liver impairment in patients receiving cytotoxic chemotherapy
Chemotherapeutic agents can affect the glomerulus, renal tubules, interstitium or microvasculature. In renal impairment, drug excretion pathways by glomerular filtration and tubular secretion are inhibited, leading to increased systemic toxicity. Dose reductions were required in many drugs based on...
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| Format: | Article |
| Language: | English |
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Prince of Songkla University
2010-02-01
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| Series: | Journal of Health Science and Medical Research (JHSMR) |
| Subjects: | |
| Online Access: | https://www.jhsmr.org/index.php/jhsmr/article/view/339 |
| _version_ | 1811345165600686080 |
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| author | Nungrutai Saeaib Arunee Dechaphunkul Patrapim Sunpaweravong |
| author_facet | Nungrutai Saeaib Arunee Dechaphunkul Patrapim Sunpaweravong |
| author_sort | Nungrutai Saeaib |
| collection | DOAJ |
| description | Chemotherapeutic agents can affect the glomerulus, renal tubules, interstitium or microvasculature. In renal impairment, drug excretion pathways by glomerular filtration and tubular secretion are inhibited, leading to increased systemic toxicity. Dose reductions were required in many drugs based on an estimation of glomerular filtration rate (GFR) and clinical signs of drug toxicity. Also, cytotoxic chemotherapy affected liver function by direct chemical reaction such as intrinsic hepatotoxicity or idiosyncratic reactions or immune mediated hypersensitivity. Therefore, liver function should be carefully assessed both prior to treatment and during therapy because an alteration of metabolism and excretion of chemotherapeutic drugs can lead to higher or more persistent drug levels, resulting in increased systemic toxicity (particularly myelosuppression) or worsening of chemotherapyinduced hepatotoxicity. |
| first_indexed | 2024-04-13T20:00:15Z |
| format | Article |
| id | doaj.art-495d77432f5047e28769e5b13a70dae2 |
| institution | Directory Open Access Journal |
| issn | 2586-9981 2630-0559 |
| language | English |
| last_indexed | 2024-04-13T20:00:15Z |
| publishDate | 2010-02-01 |
| publisher | Prince of Songkla University |
| record_format | Article |
| series | Journal of Health Science and Medical Research (JHSMR) |
| spelling | doaj.art-495d77432f5047e28769e5b13a70dae22022-12-22T02:32:14ZengPrince of Songkla UniversityJournal of Health Science and Medical Research (JHSMR)2586-99812630-05592010-02-012814959353Renal and liver impairment in patients receiving cytotoxic chemotherapyNungrutai Saeaib0Arunee Dechaphunkul1Patrapim Sunpaweravong2Department of Obstetrics and Gynecology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110,2Division of Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110,2Division of Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110,Chemotherapeutic agents can affect the glomerulus, renal tubules, interstitium or microvasculature. In renal impairment, drug excretion pathways by glomerular filtration and tubular secretion are inhibited, leading to increased systemic toxicity. Dose reductions were required in many drugs based on an estimation of glomerular filtration rate (GFR) and clinical signs of drug toxicity. Also, cytotoxic chemotherapy affected liver function by direct chemical reaction such as intrinsic hepatotoxicity or idiosyncratic reactions or immune mediated hypersensitivity. Therefore, liver function should be carefully assessed both prior to treatment and during therapy because an alteration of metabolism and excretion of chemotherapeutic drugs can lead to higher or more persistent drug levels, resulting in increased systemic toxicity (particularly myelosuppression) or worsening of chemotherapyinduced hepatotoxicity.https://www.jhsmr.org/index.php/jhsmr/article/view/339chemotherapyimpairmentliverrenalตับไตยาเคมีบำบัดเสื่อมหน้าที่ |
| spellingShingle | Nungrutai Saeaib Arunee Dechaphunkul Patrapim Sunpaweravong Renal and liver impairment in patients receiving cytotoxic chemotherapy Journal of Health Science and Medical Research (JHSMR) chemotherapy impairment liver renal ตับ ไต ยาเคมีบำบัด เสื่อมหน้าที่ |
| title | Renal and liver impairment in patients receiving cytotoxic chemotherapy |
| title_full | Renal and liver impairment in patients receiving cytotoxic chemotherapy |
| title_fullStr | Renal and liver impairment in patients receiving cytotoxic chemotherapy |
| title_full_unstemmed | Renal and liver impairment in patients receiving cytotoxic chemotherapy |
| title_short | Renal and liver impairment in patients receiving cytotoxic chemotherapy |
| title_sort | renal and liver impairment in patients receiving cytotoxic chemotherapy |
| topic | chemotherapy impairment liver renal ตับ ไต ยาเคมีบำบัด เสื่อมหน้าที่ |
| url | https://www.jhsmr.org/index.php/jhsmr/article/view/339 |
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