Cytidine deaminase activity increases in the blood of breast cancer patients

Abstract Cytidine deaminase (CDA), an enzyme of the pyrimidine salvage pathway, deaminates cytidine, deoxycytidine and analogs, such as gemcitabine. Constitutive low levels of CDA activity have been reported in the blood of patients with hematological malignancies or suffering from gemcitabine toxic...

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Bibliographic Details
Main Authors: Géraldine Buhagiar-Labarchède, Rosine Onclercq-Delic, Sophie Vacher, Frédérique Berger, Ivan Bièche, Dominique Stoppa-Lyonnet, Mounira Amor-Guéret
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-18462-8