Extracellular matrix modulates the spatial hepatic features in hepatocyte-like cells derived from human embryonic stem cells

Extracellular matrix modulates the spatial hepatic features in hepatocyte-like cells derived from human embryonic stem cells

Abstract Background Human pluripotent stem cell (hPSC)-derived hepatocyte-like cells (HLCs) can provide a valuable in vitro model for disease modelling and drug development. However, generating HLCs with characteristics comparable to hepatocytes in vivo is challenging. Extracellular matrix (ECM) pla...

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Bibliographic Details
Main Authors: Faiza Farhan, Manjari Trivedi, Priscilla Di Wu, Wei Cui
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Stem Cell Research & Therapy
Subjects:
Extracellular matrix (ECM)
Hepatocyte
hESC differentiation
Hepatic zonation
Matrigel
Collagen
Online Access:https://doi.org/10.1186/s13287-023-03542-x

Internet

https://doi.org/10.1186/s13287-023-03542-x

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