Extrinsic cell death pathway plasticity: a driver of clonal evolution in cancer?

Abstract Human cancers are known to adhere to basic evolutionary principles. During their journey from early transformation to metastatic disease, cancer cell populations have proven to be remarkably adaptive to different forms of intra- and extracellular selective pressure, including nutrient scarc...

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Bibliographic Details
Main Authors: Eric Seidel, Silvia von Karstedt
Format: Article
Language:English
Published: Nature Publishing Group 2022-11-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-022-01251-7