ABT-333 (Dasabuvir) Increases Action Potential Duration and Provokes Early Afterdepolarizations in Canine Left Ventricular Cells via Inhibition of I<sub>Kr</sub>

ABT-333 (Dasabuvir) Increases Action Potential Duration and Provokes Early Afterdepolarizations in Canine Left Ventricular Cells via Inhibition of I<sub>Kr</sub>

ABT-333 (dasabuvir) is an antiviral agent used in hepatitis C treatment. The molecule, similarly to some inhibitors of hERG channels, responsible for the delayed rectifier potassium current (I<sub>Kr</sub>), contains the methanesulfonamide group. Reduced I<sub>Kr</sub> curren...

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Bibliographic Details
Main Authors: Zsigmond Máté Kovács, József Óvári, Csaba Dienes, János Magyar, Tamás Bányász, Péter P. Nánási, Balázs Horváth, Adam Feher, Zoltan Varga, Norbert Szentandrássy
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Pharmaceuticals
Subjects:
ABT-333
dasabuvir
action potential
canine
cardiomyocyte
I<sub>Kr</sub>
Online Access:https://www.mdpi.com/1424-8247/16/4/488

Internet

https://www.mdpi.com/1424-8247/16/4/488

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