UBQLN2 restrains the domesticated retrotransposon PEG10 to maintain neuronal health in ALS

UBQLN2 restrains the domesticated retrotransposon PEG10 to maintain neuronal health in ALS

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive motor neuron dysfunction and loss. A portion of ALS cases are caused by mutation of the proteasome shuttle factor Ubiquilin 2 (UBQLN2), but the molecular pathway leading from UBQLN2 dysfunction to d...

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Bibliographic Details
Main Authors: Holly H Black, Jessica L Hanson, Julia E Roberts, Shannon N Leslie, Will Campodonico, Christopher C Ebmeier, G Aaron Holling, Jian Wei Tay, Autumn M Matthews, Elizabeth Ung, Cristina I Lau, Alexandra M Whiteley
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-03-01
Series:eLife
Subjects:
ALS
ubiquilin
proteomics
UBQLN2
domesticated retrotransposon
PEG10
Online Access:https://elifesciences.org/articles/79452

Internet

https://elifesciences.org/articles/79452

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