Sulforaphane Exerts Beneficial Immunomodulatory Effects on Liver Tissue via a Nrf2 Pathway-Related Mechanism in a Murine Model of Hemorrhagic Shock and Resuscitation

Sulforaphane Exerts Beneficial Immunomodulatory Effects on Liver Tissue via a Nrf2 Pathway-Related Mechanism in a Murine Model of Hemorrhagic Shock and Resuscitation

Our research explores the immunomodulatory effects of sulforaphane (SFN), a well-known nuclear factor erythroid 2-related factor 2 (Nrf2) pathway agonist, on the sterile inflammation of and ischemia-reperfusion injuries to the liver after hemorrhagic shock (HS) followed by resuscitation (R). Male C5...

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Bibliographic Details
Main Authors: Weiqiang Liang, Johannes Greven, Kang Qin, Athanassios Fragoulis, Klemens Horst, Felix Bläsius, Christoph Wruck, Thomas Pufe, Philipp Kobbe, Frank Hildebrand, Philipp Lichte
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Immunology
Subjects:
hemorrhagic shock/resuscitation
liver
ischemia-reperfusion injury
cytokines
Kupffer Cells
sulforaphane
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.822895/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.822895/full

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