Computational Insights into the Sequence-Activity Relationships of the NGF(1–14) Peptide by Molecular Dynamics Simulations

Computational Insights into the Sequence-Activity Relationships of the NGF(1–14) Peptide by Molecular Dynamics Simulations

The Nerve Growth Factor (NGF) belongs to the neurothrophins protein family involved in the survival of neurons in the nervous system. The interaction of NGF with its high-affinity receptor TrkA mediates different cellular pathways related to Alzheimer’s disease, pain, ocular dysfunction, and cancer....

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Bibliographic Details
Main Authors: Serena Vittorio, Candida Manelfi, Silvia Gervasoni, Andrea R. Beccari, Alessandro Pedretti, Giulio Vistoli, Carmine Talarico
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cells
Subjects:
Nerve Growth Factor
TrkA
molecular dynamics
MM-GBSA
per-residue energy decomposition
Online Access:https://www.mdpi.com/2073-4409/11/18/2808

Internet

https://www.mdpi.com/2073-4409/11/18/2808

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