Oxidative stress-induced premature senescence and aggravated denervated skeletal muscular atrophy by regulating progerin–p53 interaction

Oxidative stress-induced premature senescence and aggravated denervated skeletal muscular atrophy by regulating progerin–p53 interaction

Abstract Background Progerin elevates atrophic gene expression and helps modify the nuclear membrane to cause severe muscle pathology, which is similar to muscle weakness in the elderly, to alter the development and function of the skeletal muscles. Stress-induced premature senescence (SIPS), a stat...

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Bibliographic Details
Main Authors: Yaoxian Xiang, Zongqi You, Xinying Huang, Junxi Dai, Junpeng Zhang, Shuqi Nie, Lei Xu, Junjian Jiang, Jianguang Xu
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Skeletal Muscle
Subjects:
ROS
NO
Denervated muscle atrophy
Progerin
P53
Online Access:https://doi.org/10.1186/s13395-022-00302-y

Internet

https://doi.org/10.1186/s13395-022-00302-y

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