Staphylococcal Superantigens Stimulate Epithelial Cells through CD40 To Produce Chemokines

Staphylococcal Superantigens Stimulate Epithelial Cells through CD40 To Produce Chemokines

ABSTRACT Mucosal and skin tissues form barriers to infection by most bacterial pathogens. Staphylococcus aureus causes diseases across these barriers in part dependent on the proinflammatory properties of superantigens. We showed, through use of a CRISPR-Cas9 CD40 knockout, that the superantigens to...

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Bibliographic Details
Main Authors: Patrick M. Schlievert, Michael P. Cahill, Bruce S. Hostager, Amanda J. Brosnahan, Aloysius J. Klingelhutz, Francoise A. Gourronc, Gail A. Bishop, Donald Y. M. Leung
Format: Article
Language:English
Published: American Society for Microbiology 2019-04-01
Series:mBio
Subjects:
CD40
Staphylococcus aureus
chemokines
superantigens
toxic shock syndrome toxin
Online Access:https://journals.asm.org/doi/10.1128/mBio.00214-19

Internet

https://journals.asm.org/doi/10.1128/mBio.00214-19

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