Synthesis of fluorinated triphenylphosphonium analogs that improve cancer cell selectivity and in vivo detection

Synthesis of fluorinated triphenylphosphonium analogs that improve cancer cell selectivity and in vivo detection

Summary: Triphenylphosphonium (TPP+) compounds like mito-metformin (MMe) target cancer cells by exploiting their hyperpolarized mitochondrial membrane potential. Here, we present a protocol for synthesizing TPP+ analogs with selectivity for mammalian cancer cells, reduced toxicity, and quantifiabili...

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Bibliographic Details
Main Authors: Robert F. Keyes, Donna McAllister, Michael B. Dwinell, Brian C. Smith
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:STAR Protocols
Subjects:
Cancer
Chemistry
Metabolism
Model Organisms
NMR
Online Access:http://www.sciencedirect.com/science/article/pii/S2666166723004045

Internet

http://www.sciencedirect.com/science/article/pii/S2666166723004045

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