Thrombomodulin is associated with increased mortality and organ failure in mechanically ventilated children with acute respiratory failure: biomarker analysis from a multicenter randomized controlled trial

Thrombomodulin is associated with increased mortality and organ failure in mechanically ventilated children with acute respiratory failure: biomarker analysis from a multicenter randomized controlled trial

Abstract Background Acute respiratory failure (ARF) can progress to acute respiratory distress syndrome and death. Biomarkers may allow for risk stratification and prognostic enrichment in ARF. Thrombomodulin (TM) is a transmembrane antithrombotic mediator expressed in endothelial cells. It is cleav...

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Bibliographic Details
Main Authors: Ana Carolina Costa Monteiro, Heidi Flori, Mary K. Dahmer, Myung Shin Sim, Michael W. Quasney, Martha A. Q. Curley, Michael A. Matthay, Anil Sapru, for the BALI Study Investigators of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Critical Care
Subjects:
Acute respiratory distress syndrome
Acute respiratory failure
Dead space ventilation
Thrombomodulin
Coagulation
Vascular injury
Online Access:https://doi.org/10.1186/s13054-021-03626-1

Internet

https://doi.org/10.1186/s13054-021-03626-1

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