Bioenergetic state regulates innate inflammatory responses through the transcriptional co-repressor CtBP

Bioenergetic state regulates innate inflammatory responses through the transcriptional co-repressor CtBP

Several metabolic factors affect cellular glucose metabolism as well as the innate inflammatory response. Here, the authors show that glucose metabolism regulates pro-inflammatory responses through effects on the cytosolic NADH:NAD+ ratio and the NAD(H)-sensitive transcription co-repressor CtBP.

Bibliographic Details
Main Authors: Yiguo Shen, David Kapfhamer, Angela M. Minnella, Ji-Eun Kim, Seok Joon Won, Yanting Chen, Yong Huang, Ley Hian Low, Stephen M. Massa, Raymond A. Swanson
Format: Article
Language:English
Published: Nature Portfolio 2017-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00707-0

Internet

https://doi.org/10.1038/s41467-017-00707-0

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