Queuine Is a Nutritional Regulator of <named-content content-type="genus-species">Entamoeba histolytica</named-content> Response to Oxidative Stress and a Virulence Attenuator

Queuine Is a Nutritional Regulator of <named-content content-type="genus-species">Entamoeba histolytica</named-content> Response to Oxidative Stress and a Virulence Attenuator

ABSTRACT Queuosine is a naturally occurring modified ribonucleoside found in the first position of the anticodon of the transfer RNAs for Asp, Asn, His, and Tyr. Eukaryotes lack pathways to synthesize queuine, the nucleobase precursor to queuosine, and must obtain it from diet or gut microbiota. Her...

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Bibliographic Details
Main Authors: Shruti Nagaraja, Maggi W. Cai, Jingjing Sun, Hugo Varet, Lotem Sarid, Meirav Trebicz-Geffen, Yana Shaulov, Mohit Mazumdar, Rachel Legendre, Jean-Yves Coppée, Thomas J. Begley, Peter C. Dedon, Samudrala Gourinath, Nancy Guillen, Yumiko Saito-Nakano, Chikako Shimokawa, Hajime Hisaeda, Serge Ankri
Format: Article
Language:English
Published: American Society for Microbiology 2021-04-01
Series:mBio
Subjects:
Entamoeba histolytica
oxidative stress
tRNA modification
virulence
Online Access:https://journals.asm.org/doi/10.1128/mBio.03549-20

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https://journals.asm.org/doi/10.1128/mBio.03549-20

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