CD8+ T cell/cancer-associated fibroblast ratio stratifies prognostic and predictive responses to immunotherapy across multiple cancer types

CD8+ T cell/cancer-associated fibroblast ratio stratifies prognostic and predictive responses to immunotherapy across multiple cancer types

BackgroundCancer-associated fibroblasts (CAFs) within the tumor microenvironment (TME) are critical for immune suppression by restricting immune cell infiltration in the tumor stromal zones from penetrating tumor islands and changing their function status, particularly for CD8+ T cells. However, ass...

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Bibliographic Details
Main Authors: Xinlong Zheng, Kan Jiang, Weijin Xiao, Dongqiang Zeng, Wenying Peng, Jing Bai, Xiaohui Chen, Pansong Li, Longfeng Zhang, Xiaobin Zheng, Qian Miao, Haibo Wang, Shiwen Wu, Yiquan Xu, Haipeng Xu, Chao Li, Lifeng Li, Xuan Gao, Suya Zheng, Junhui Li, Deqiang Wang, Zhipeng Zhou, Xuefeng Xia, Shanshan Yang, Yujing Li, Zhaolei Cui, Qiuyu Zhang, Ling Chen, Xiandong Lin, Gen Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
CD8+ T cell
cancer-associated fibroblast
prognostic biomarker
predictive biomarker
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.974265/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.974265/full

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