Cancer Cells Haploinsufficient for ATM Are Sensitized to PARP Inhibitors by <i>MET</i> Inhibition

Cancer Cells Haploinsufficient for ATM Are Sensitized to PARP Inhibitors by <i>MET</i> Inhibition

The <i>MET</i> oncogene encodes a tyrosine kinase (TK) receptor. Its activation protects cells from death but also stimulates DNA damage response by triggering excess replicative stress. Transcriptomic classification of cancer cell lines based on <i>MET</i> expression showed...

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Bibliographic Details
Main Authors: Concetta D’Ambrosio, Jessica Erriquez, Sonia Capellero, Simona Cignetto, Maria Alvaro, Eric Ciamporcero, Maria Flavia Di Renzo, Timothy Perera, Giorgio Valabrega, Martina Olivero
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:International Journal of Molecular Sciences
Subjects:
ovarian cancer
PARP inhibitor
<i>MET</i>
ATM
resistance
Online Access:https://www.mdpi.com/1422-0067/23/10/5770

Internet

https://www.mdpi.com/1422-0067/23/10/5770

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