High Dose IFN-β Activates GAF to Enhance Expression of ISGF3 Target Genes in MLE12 Epithelial Cells

High Dose IFN-β Activates GAF to Enhance Expression of ISGF3 Target Genes in MLE12 Epithelial Cells

Interferon β (IFN-β) signaling activates the transcription factor complex ISGF3 to induce gene expression programs critical for antiviral defense and host immune responses. It has also been observed that IFN-β activates a second transcription factor complex, γ-activated factor (GAF), but the signifi...

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Bibliographic Details
Main Authors: Kensei Kishimoto, Catera L. Wilder, Justin Buchanan, Minh Nguyen, Chidera Okeke, Alexander Hoffmann, Quen J. Cheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
interferon
JAK-STAT signaling pathway
signal transduction
gene regulation
ISGF3
GAF
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.651254/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.651254/full

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