Erasing m6A-dependent transcription signature of stress-sensitive genes triggers antidepressant actions

Erasing m6A-dependent transcription signature of stress-sensitive genes triggers antidepressant actions

Emerging evidence has shown that stress responsivity and psychiatric diseases are associated with alterations in N6-methyladenosine (m6A) mRNA epigenetic modifications. Fat mass and obesity-associated protein (FTO) is an m6A demethylase that has been linked to increased body mass and obesity. Here,...

Full description

Bibliographic Details
Main Authors: Peng-Fei Wu, Qian-Qian Han, Fu-Feng Chen, Tian-Tian Shen, Yi-Heng Li, Yu Cao, Jian-Guo Chen, Fang Wang
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Neurobiology of Stress
Subjects:
Depression
Stress vulnerability
Tricyclic antidepressant
N6-methyladenosine
FTO
Online Access:http://www.sciencedirect.com/science/article/pii/S2352289521000989

Internet

http://www.sciencedirect.com/science/article/pii/S2352289521000989

Similar Items