Differential prolyl hydroxylation by six Physcomitrella prolyl-4 hydroxylases

Differential prolyl hydroxylation by six Physcomitrella prolyl-4 hydroxylases

Hydroxylation of prolines to 4-trans-hydroxyproline (Hyp) is mediated by prolyl-4 hydroxylases (P4Hs). In plants, Hyps occur in Hydroxyproline-rich glycoproteins (HRGPs), and are frequently O-glycosylated. While both modifications are important, e.g. for cell wall stability, they are undesired in pl...

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Bibliographic Details
Main Authors: Christine Rempfer, Sebastian N.W. Hoernstein, Nico van Gessel, Andreas W. Graf, Roxane P. Spiegelhalder, Anne Bertolini, Lennard L. Bohlender, Juliana Parsons, Eva L. Decker, Ralf Reski
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Biopharmaceutical
Erythropoietin
O-glycosylation
Plant-made pharmaceutical
Posttranslational protein modification
Prolyl-hydroxylation
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037024002113

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http://www.sciencedirect.com/science/article/pii/S2001037024002113

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