D-Cysteine Ethyl Ester Reverses the Deleterious Effects of Morphine on Breathing and Arterial Blood–Gas Chemistry in Freely-Moving Rats

D-Cysteine Ethyl Ester Reverses the Deleterious Effects of Morphine on Breathing and Arterial Blood–Gas Chemistry in Freely-Moving Rats

Cell-penetrant thiol esters including the disulfides, D-cystine diethyl ester and D-cystine dimethyl ester, and the monosulfide, L-glutathione ethyl ester, prevent and/or reverse the deleterious effects of opioids, such as morphine and fentanyl, on breathing and gas exchange within the lungs of unan...

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Bibliographic Details
Main Authors: Paulina M. Getsy, Santhosh M. Baby, Walter J. May, Alex P. Young, Benjamin Gaston, Matthew R. Hodges, Hubert V. Forster, James N. Bates, Christopher G. Wilson, Tristan H. J. Lewis, Yee-Hee Hsieh, Stephen J. Lewis
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
D-cysteine ethyl ester
thiol esters
morphine
respiratory depression
gas exchange
antinociception
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.883329/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.883329/full

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