Sex-specific developmental alterations in DYRK1A expression in the brain of a Down syndrome mouse model

Sex-specific developmental alterations in DYRK1A expression in the brain of a Down syndrome mouse model

Aberrant neurodevelopment in Down syndrome (DS)—caused by triplication of human chromosome 21—is commonly attributed to gene dosage imbalance, linking overexpression of trisomic genes with disrupted developmental processes, with DYRK1A particularly implicated. We hypothesized that regional brain DYR...

Full description

Bibliographic Details
Main Authors: Laura E. Hawley, Megan Stringer, Abigail J. Deal, Andrew Folz, Charles R. Goodlett, Randall J. Roper
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Neurobiology of Disease
Subjects:
Down syndrome
Neonatal
Development
Cerebral cortex
Cerebellum
Hippocampus
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123003753

Internet

http://www.sciencedirect.com/science/article/pii/S0969996123003753

Similar Items