Targeting uridine–cytidine kinase 2 induced cell cycle arrest through dual mechanism and could improve the immune response of hepatocellular carcinoma

Targeting uridine–cytidine kinase 2 induced cell cycle arrest through dual mechanism and could improve the immune response of hepatocellular carcinoma

Abstract Background Pyrimidine metabolism is critical for tumour progression. Uridine–cytidine kinase 2 (UCK2), a key regulator of pyrimidine metabolism, is elevated during hepatocellular carcinoma (HCC) development and exhibits carcinogenic effects. However, the key mechanism of UCK2 promoting HCC...

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Bibliographic Details
Main Authors: Dehai Wu, Congyi Zhang, Guanqun Liao, Kaiming Leng, Bowen Dong, Yang Yu, Huilin Tai, Lining Huang, Feng Luo, Bin Zhang, Tiexiang Zhan, Qiuhui Hu, Sheng Tai
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Cellular & Molecular Biology Letters
Subjects:
Uridine–cytidine kinase 2
Hepatocellular carcinoma
Microenvironment
Secretory phenotype
Pyrimidine metabolism
Online Access:https://doi.org/10.1186/s11658-022-00403-y

Internet

https://doi.org/10.1186/s11658-022-00403-y

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