ZnT8 loss-of-function accelerates functional maturation of hESC-derived β cells and resists metabolic stress in diabetes

ZnT8 loss-of-function accelerates functional maturation of hESC-derived β cells and resists metabolic stress in diabetes

Immature function and fragility hinder application of hESC-derived β cells (SC-β cell) for diabetes cell therapy. Here, the authors identify ZnT8 as a gene editing target to enhance the insulin secretion and cell survival under metabolic stress by abolishing zinc transport in SC-β cells.

Bibliographic Details
Main Authors: Qing Ma, Yini Xiao, Wenjun Xu, Menghan Wang, Sheng Li, Zhihao Yang, Minglu Xu, Tengjiao Zhang, Zhen-Ning Zhang, Rui Hu, Qiang Su, Fei Yuan, Tinghui Xiao, Xuan Wang, Qing He, Jiaxu Zhao, Zheng-jun Chen, Zhejin Sheng, Mengyao Chai, Hong Wang, Weiyang Shi, Qiaolin Deng, Xin Cheng, Weida Li
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-31829-9

Internet

https://doi.org/10.1038/s41467-022-31829-9

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