A graph neural network-based interpretable framework reveals a novel DNA fragility–associated chromatin structural unit

A graph neural network-based interpretable framework reveals a novel DNA fragility–associated chromatin structural unit

Abstract Background DNA double-strand breaks (DSBs) are among the most deleterious DNA lesions, and they can cause cancer if improperly repaired. Recent chromosome conformation capture techniques, such as Hi-C, have enabled the identification of relationships between the 3D chromatin structure and D...

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Bibliographic Details
Main Authors: Yu Sun, Xiang Xu, Lin Lin, Kang Xu, Yang Zheng, Chao Ren, Huan Tao, Xu Wang, Huan Zhao, Weiwei Tu, Xuemei Bai, Junting Wang, Qiya Huang, Yaru Li, Hebing Chen, Hao Li, Xiaochen Bo
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Genome Biology
Subjects:
DSB
3D chromatin structure
Interpretability
Graph neural network
Online Access:https://doi.org/10.1186/s13059-023-02916-x

Internet

https://doi.org/10.1186/s13059-023-02916-x

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