Developmental diet regulates Drosophila lifespan via lipid autotoxins
The diet consumed during development can have long-lasting effects on adult physiology. Here, the authors show that developmental undernutrition in Drosophila extends lifespan by inhibiting the production of toxic lipids, called autotoxins, on the adult body surface.
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-01740-9 |
| _version_ | 1824013475038363648 |
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| author | M. Irina Stefana Paul C. Driscoll Fumiaki Obata Ana Raquel Pengelly Clare L. Newell James I. MacRae Alex P. Gould |
| author_facet | M. Irina Stefana Paul C. Driscoll Fumiaki Obata Ana Raquel Pengelly Clare L. Newell James I. MacRae Alex P. Gould |
| author_sort | M. Irina Stefana |
| collection | DOAJ |
| description | The diet consumed during development can have long-lasting effects on adult physiology. Here, the authors show that developmental undernutrition in Drosophila extends lifespan by inhibiting the production of toxic lipids, called autotoxins, on the adult body surface. |
| first_indexed | 2024-12-18T22:02:05Z |
| format | Article |
| id | doaj.art-49964fcd24ae4bed8845eb15473aa509 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T22:02:05Z |
| publishDate | 2017-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-49964fcd24ae4bed8845eb15473aa5092022-12-21T20:50:16ZengNature PortfolioNature Communications2041-17232017-11-018111310.1038/s41467-017-01740-9Developmental diet regulates Drosophila lifespan via lipid autotoxinsM. Irina Stefana0Paul C. Driscoll1Fumiaki Obata2Ana Raquel Pengelly3Clare L. Newell4James I. MacRae5Alex P. Gould6The Francis Crick InstituteThe Francis Crick InstituteThe Francis Crick InstituteThe Francis Crick InstituteThe Francis Crick InstituteThe Francis Crick InstituteThe Francis Crick InstituteThe diet consumed during development can have long-lasting effects on adult physiology. Here, the authors show that developmental undernutrition in Drosophila extends lifespan by inhibiting the production of toxic lipids, called autotoxins, on the adult body surface.https://doi.org/10.1038/s41467-017-01740-9 |
| spellingShingle | M. Irina Stefana Paul C. Driscoll Fumiaki Obata Ana Raquel Pengelly Clare L. Newell James I. MacRae Alex P. Gould Developmental diet regulates Drosophila lifespan via lipid autotoxins Nature Communications |
| title | Developmental diet regulates Drosophila lifespan via lipid autotoxins |
| title_full | Developmental diet regulates Drosophila lifespan via lipid autotoxins |
| title_fullStr | Developmental diet regulates Drosophila lifespan via lipid autotoxins |
| title_full_unstemmed | Developmental diet regulates Drosophila lifespan via lipid autotoxins |
| title_short | Developmental diet regulates Drosophila lifespan via lipid autotoxins |
| title_sort | developmental diet regulates drosophila lifespan via lipid autotoxins |
| url | https://doi.org/10.1038/s41467-017-01740-9 |
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