Arachidonate 15-lipoxygenase-mediated production of Resolvin D5n-3 DPA abrogates pancreatic stellate cell-induced cancer cell invasion

Arachidonate 15-lipoxygenase-mediated production of Resolvin D5n-3 DPA abrogates pancreatic stellate cell-induced cancer cell invasion

Activation of pancreatic stellate cells (PSCs) to cancer-associated fibroblasts (CAFs) is responsible for the extensive desmoplastic reaction observed in PDAC stroma: a key driver of pancreatic ductal adenocarcinoma (PDAC) chemoresistance leading to poor prognosis. Specialized pro-resolving mediator...

Full description

Bibliographic Details
Main Authors: Gabriel A. Aguirre, Michelle R. Goulart, Barts Pancreas Tissue Bank, Jesmond Dalli, Hemant M. Kocher
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Immunology
Subjects:
pancreatic ductal adenocarcinoma
specialized pro-resolving mediator
lipid mediator
cancer-associated fibroblast
all-trans retinoic acid
ALOX15
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1248547/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1248547/full

Similar Items