Involvement of Ferroptosis Induction and Oxidative Phosphorylation Inhibition in the Anticancer-Drug-Induced Myocardial Injury: Ameliorative Role of Pterostilbene

Involvement of Ferroptosis Induction and Oxidative Phosphorylation Inhibition in the Anticancer-Drug-Induced Myocardial Injury: Ameliorative Role of Pterostilbene

Patients with cancer die from cardiac dysfunction second only to the disease itself. Cardiotoxicity caused by anticancer drugs has been emphasized as a possible cause; however, the details remain unclear. To investigate this mechanism, we treated rat cardiomyoblast H9c2 cells with sunitinib, lapatin...

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Bibliographic Details
Main Authors: Kiyomu Fujii, Rina Fujiwara-Tani, Shota Nukaga, Hitoshi Ohmori, Yi Luo, Ryoichi Nishida, Takamitsu Sasaki, Yoshihiro Miyagawa, Chie Nakashima, Isao Kawahara, Ruiko Ogata, Ayaka Ikemoto, Rika Sasaki, Hiroki Kuniyasu
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:International Journal of Molecular Sciences
Subjects:
drug-induced cardiac damage
ferroptosis
mitochondrial damage
mitochondrial iron
pterostilbene
antioxidants
Online Access:https://www.mdpi.com/1422-0067/25/5/3015

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https://www.mdpi.com/1422-0067/25/5/3015

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