Novel DNA methylome biomarkers associated with adalimumab response in rheumatoid arthritis patients

Novel DNA methylome biomarkers associated with adalimumab response in rheumatoid arthritis patients

Background and aimsRheumatoid arthritis (RA) patients are currently treated with biological agents mostly aimed at cytokine blockade, such as tumor necrosis factor-alpha (TNFα). Currently, there are no biomarkers to predict therapy response to these agents. Here, we aimed to predict response to adal...

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Bibliographic Details
Main Authors: Ishtu Hageman, Femke Mol, Sadaf Atiqi, Vincent Joustra, Hilal Sengul, Peter Henneman, Ingrid Visman, Theodorus Hakvoort, Mike Nurmohamed, Gertjan Wolbink, Evgeni Levin, Andrew Y.F. Li Yim, Geert D’Haens, Wouter J. de Jonge
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Immunology
Subjects:
DNA methylation
rheumatoid arthritis
adalimumab
machine learning
therapy response
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1303231/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1303231/full

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